Publications by authors named "P Challa"
The performing of non-physician led exercise stress testing with and without echocardiography has shown similar diagnostic utility and safety as physician led models. While diagnostic accuracy and relative safety have been the focus of previous research, the current study aims to demonstrate efficiencies not previously reported such as reduction in wait times for testing and improved service attendance. A non-physician led exercise stress echocardiography (ESE) service was implemented on 01/01/2018, prior to this all tests were performed under a physician led model.
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- Ocular hypertension, a key risk factor for glaucoma, is linked to increased activity and stiffness in the trabecular meshwork (TM) due to cellular interactions.
- Previous research identified high levels of septin-9 in TM cells under hypertensive conditions, prompting studies on its overexpression, deficiency, and drug targeting effects.
- Findings indicate that septin-9 impacts intraocular pressure (IOP) regulation, suggesting that modulating septin cytoskeletal organization could be a potential new treatment strategy for glaucoma.
Article Synopsis
- - Outcomes for patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) are generally poor; however, the FDA approved Loncastuximab-teserine (Lonca) based on the LOTIS-2 trial results for those who have undergone at least two prior treatments.
- - A retrospective study analyzed 187 patients from 21 US centers treated with Lonca, revealing a complete response rate of 14% and an overall response rate of 32%, indicating lower efficacy in a real-world setting compared to the original trial.
- - Patients in this study had higher risk features, including bulky disease and high-grade B-cell histology, leading to poorer median event-free survival (2.1 months
Background: Cutaneous leishmaniasis (CL) ulcers exhibiting an inflammatory phenotype, characterized by purulent exudate, erythema, pain, and/or lymphatic involvement, are empirically treated with antibiotics.
Objective: The spectrum of bacteria present in localized versus inflammatory phenotypes of CL is elucidated herein.
Methods: Filter paper lesion impressions (FPLIs) from 39 patients with CL (19 inflammatory and 20 noninflammatory ulcers) were evaluated via real-time polymerase chain reaction (qPCR) and end-point PCR targeting: , , , spp.