Publications by authors named "P Celli"
Background: COVID-19 vaccines reduced mortality, hospitalizations and ICUs admissions. Conversely, the impact of vaccination on Long COVID-19 syndrome is still unclear. This study compared the prevalence of post-acute sequelae at short and long-term follow-up among hospitalized unvaccinated and vaccinated COVID-19 survivors through a multidisciplinary approach.
View Article and Find Full Text PDFAims: Sudden cardiac death (SCD) is a serious consequence of a myocardial infarction (MI), but identifying patients at risk of developing SCD remains a major clinical challenge, especially in the case of juvenile MI. The aim of this study is to identify predictors of SCD after early-onset MI using long-term follow-up data relating to a large nationwide patient cohort.
Methods And Results: The Italian Genetic Study on Early-onset MI enrolled 2000 patients experiencing a first MI before the age of 45 years, who were followed up for a median of 19.
Article Synopsis
- The study compared transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement (SAVR) in low-risk patients, finding no significant differences in all-cause mortality, disabling stroke, or major cardiovascular events between the two procedures.
- TAVR patients experienced more paravalvular leaks but had fewer cases of new-onset atrial fibrillation compared to those undergoing SAVR.
- Overall, TAVR demonstrated similar long-term safety and effectiveness to SAVR, along with a greater effective orifice area but akin transvalvular mean gradients.
Article Synopsis
- The study reviews current literature on the outcomes of surgical aortic valve replacement (SAVR) versus transcatheter aortic valve replacement (TAVR) specifically for patients with bicuspid aortic stenosis (BAS), focusing on different valve morphologies in TAVR patients.
- It analyzed eight studies comparing SAVR and TAVR outcomes, revealing no significant differences in death, stroke, or acute kidney injury rates between both methods, though TAVR had more permanent pacemaker implantations and SAVR had higher bleeding events.
- The findings suggest that while TAVR is comparable to SAVR in short-term outcomes for BAS, it is associated with a higher rate of pacemaker use and lower rates of bleeding.
Positive predictive values and outcomes for uninformative cell-free DNA tests: An Italian multicentric Cytogenetic and cytogenomic Audit of diagnOstic testing (ICARO study).
Prenat Diagn
December 2022
Objectives: To establish the positive predictive values (PPV) of cfDNA testing based on data from a nationwide survey of independent clinical cytogenetics laboratories.
Methods: Prenatal diagnostic test results obtained by Italian laboratories between 2013 and March 2020 were compiled for women with positive non-invasive prenatal tests (NIPT), without an NIPT result, and cases where there was sex discordancy between the NIPT and ultrasound. PPV and other summary data were reviewed.