Publications by authors named "P Celerier"
Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne.
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- The study examines the differences between solar melanomas (like LMM) and non-solar melanomas (like ALM), highlighting that ALM is not influenced by chronic sun exposure.
- Researchers analyzed data from 1,056 Caucasian patients diagnosed with ALM and LMM between 2012 and 2020.
- Findings suggest that ALM has a less favorable prognosis than LMM, indicating that non-solar melanomas may be more aggressive, stressing the need for sentinel lymph node biopsies in ALM cases.
Background: First-degree relatives (FDRs, defined as parents, children, and siblings) of melanoma patients are at a two-to-fivefold increased risk of developing melanoma themselves. FDRs are advised to perform self-skin examination (SSE) and annual medical total cutaneous examination (TCE) performed either by a dermatologist or a general practitioner, and to change their sun-related behavior. This advice is given orally to melanoma patients who are asked to relay the information to their FDRs.
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- Cemiplimab has shown promise in real-world use for locally advanced and metastatic cutaneous squamous-cell carcinomas (CSCCs), with a best overall response rate of 50.4% among treated patients.
- There was a median progression-free survival (PFS) of 7.9 months, and one-year overall survival (OS) was 73% for patients with better performance status (PS < 2).
- Although some patients experienced severe adverse events, the overall safety and efficacy indicate cemiplimab may be a beneficial treatment option, especially for immunocompromised individuals.