Publications by authors named "P Castellucci"
Background: The modern approach to treating rectal cancer, which involves total mesorectal excision directed by imaging assessments, has significantly enhanced patient outcomes. However, locally recurrent rectal cancer (LRRC) continues to be a significant clinical issue. Identifying LRRC through imaging is complex, due to the mismatch between fibrosis and inflammatory pelvic tissue.
View Article and Find Full Text PDFPositron Emission Tomography (PET) is a crucial imaging modality in oncology, providing functional insights by detecting metabolic activity in tissues. Total-body (TB) PET and large field-of-view PET have emerged as advanced techniques, offering whole-body imaging in a single acquisition. TB PET enables simultaneous imaging from head to toe, providing comprehensive information on tumor distribution, metastasis, and treatment response.
View Article and Find Full Text PDFArticle Synopsis
- * Current guidelines recommend using Tc-Bone Scintigraphy and Contrast-Enhanced CT for staging metastatic prostate cancer, but new imaging techniques like PSMA-PET/CT and whole-body MRI (WB-MRI) show promising advantages.
- * WB-MRI combines high-resolution imaging with functional sequences, allowing for a thorough assessment of the disease without the drawbacks of radiation or contrast agents, and although its research is still developing, it suggests a strong case for inclusion in standard cancer care alongside nuclear medicine techniques.
Article Synopsis
- The study focuses on a protein called PSMA found in prostate tissue, which helps doctors use a special scan (PSMA-PET) to check for prostate cancer (PCa).
- Researchers looked at samples from 43 men with high-risk PCa who had these scans to understand how their biopsy results (samples taken from the prostate) matched up with the scan results.
- They found that less than 20% of PSMA-negative areas in the biopsies showed better agreement in results, but overall, different scores showed only a moderate match between the biopsy and final pathology.