Publications by authors named "P Casale"
Optimization of swim depth across diverse taxa during horizontal travel.
Proc Natl Acad Sci U S A
December 2024
Semiaquatic taxa, including humans, often swim at the air-water interface where they waste energy generating surface waves. For fully marine animals however, theory predicts the most cost-efficient depth-use pattern for migrating, air-breathing species that do not feed in transit is to travel at around 2 to 3 times the depth of their body diameter, to minimize the vertical distance traveled while avoiding wave drag close to the surface. This has rarely been examined, however, due to depth measurement resolution issues at the surface.
View Article and Find Full Text PDFNK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resistance is an important immune-therapeutic aim. Here, we identify autophagy as a central regulator of NK cell anti-tumor function.
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- This study examines how the Mayo Adhesive Probability (MAP) score and body mass index (BMI) affect kidney function decline after patients undergo robotic assisted partial nephrectomy (RAPN).
- A total of 258 patients were analyzed over a median follow-up of 33 months, revealing that a higher MAP score and increased BMI are correlated with a greater risk of developing chronic kidney disease stage 3 (CKD-S3).
- The findings suggest that higher MAP scores and obesity can negatively impact long-term kidney function, indicating a need for careful monitoring before surgery in at-risk patients.
Article Synopsis
- The study aimed to compare the effectiveness of high-resolution micro-ultrasound-guided transrectal biopsy (TRBx) versus MRI/conventional transrectal ultrasound-guided transperineal biopsy (TPBx) in detecting clinically significant prostate cancer (csPCa).
- Researchers analyzed data from 1,423 men who underwent prostate biopsies and found no significant difference in csPCa detection rates between the two methods (45% for TRBx and 51% for TPBx).
- The study identified key predictors for csPCa detection, including family history, age, positive digital rectal exam results, prostate-specific antigen density, and specific imaging scores, while noting limitations like the retrospective nature of the data analysis.