Publications by authors named "P Carrier"
Background: Data on the management of Hepatitis B-Delta (HB-D) by hepatogastroenterologists (HGs) practicing in nonacademic hospitals or private practices are unknown in France.
Objective: We aimed to evaluate the knowledge and practices of HGs practicing in nonacademic settings regarding HB-D.
Methods: A Google form document was sent to those HGs from May to September 2021.
Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development. We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifications (PTMs) of human serum albumin resulting from hepatocyte dysfunctions and further evaluated its performance in an animal model. The SEB test consists in spiking serum ex-vivo with ligands having specific binding sites related to the most relevant albumin PTMs and measuring their unbound fraction.
View Article and Find Full Text PDFBackground And Aim: Germline mutations of telomere-related genes (TRG) induce multiorgan dysfunction, and liver-specific manifestations have not been clearly outlined. We aimed to describe TRG mutations-associated liver diseases.
Approach And Results: Retrospective multicenter analysis of liver disease (transaminases > 30 IU/L and/or abnormal liver imaging) in patients with TRG mutations.
Article Synopsis
- * MRS significantly lowered the curative resection rate (41.6%) compared to lesions without MRS (81.3%) and increased rates of perforation and need for secondary surgeries.
- * The study suggests that if MRS is detected, ESD should be halted for colon lesions due to poor outcomes but can continue for rectal lesions due to higher risks associated with alternative treatments.