Publications by authors named "P Cappellano"
Article Synopsis
- Zoonotic sporotrichosis is a neglected fungal disease mainly caused by Sporothrix brasiliensis, transmitted from cats to humans, with a significant outbreak currently occurring in Brazil.
- The study involved whole-genome sequencing of Sporothrix isolates collected from sporotrichosis cases in Brazil, Colombia, and the USA between 2013 and 2022, aiming to explore the genomic epidemiology of the disease.
- Out of 72 isolates studied, 93% were from Brazil, with the majority being S. brasiliensis; comprehensive phylogenetic analyses revealed distinct genetic clades correlating with geographical origins and diverse transmission pathways.
Bimodal distribution of azole susceptibility in isolates in Brazil.
Amanda Ribeiro Dos Santos Lalitha Gade Elizabeth Misas Anastasia P Litvintseva Natalie S Nunnally Paola Cappellano
Antimicrob Agents Chemother
April 2024
Article Synopsis
- An emerging fungal pathogen called Sporothrix spp. poses treatment challenges, especially in human and cat sporotrichosis cases.
- Antifungal testing on 61 isolates from Brazil revealed that about 50% exhibited high resistance to itraconazole.
- Phylogenetic analysis showed that resistant isolates come from diverse clades, and SNP analysis identified a specific gene mutation linked to azole resistance in two isolates, but no other resistance mechanisms were found in the others.
Carbapenem-resistant Klebsiella pneumoniae bloodstream infections in haematological malignances and hematopoietic stem cell transplantation: Clinical impact of combination therapy in a 10-year Brazilian cohort.
Ingvar Ludwig Augusto de Souza Paola Cappellano Diogo Boldim Ferreira Maria Daniela Bergamasco Thomas Cardoso das Chagas Neto
PLoS One
January 2024
Article Synopsis
- Bacterial bloodstream infections (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (CRKp) are prevalent in patients with hematological malignancies and stem cell transplant recipients.
- A study of 65 BSI episodes over 10 years identified acute leukemias as the most common underlying condition and highlighted mucosal barrier injury in the gastrointestinal tract as the primary cause of infection.
- The research found that timely and appropriate antibiotic treatment significantly improved survival rates, while factors like hypotension at presentation and concurrent invasive fungal diseases were linked to higher 30-day mortality.