Publications by authors named "P Cancemi"
Article Synopsis
- Multiple sclerosis (MS) is a disease where the immune system attacks the protective covering of nerves, causing problems in the brain.
- Researchers are creating tiny particles called myelin-based nanovesicles (MyVes) that can help calm the immune system and protect brain cells from attack.
- MyVes have shown promise in experiments, as they can reach the brain and encourage the production of helpful anti-inflammatory substances in MS patients’ bodies.
Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which can be counteracted by the inhibition of α-glucosidase (α-Glu) and α-amylase (α-Amy), enzymes responsible for the hydrolysis of carbohydrates. In recent decades, many natural compounds and their bioinspired analogues have been studied as α-Glu and α-Amy inhibitors. However, no studies have been devoted to the evaluation of α-Glu and α-Amy inhibition by the neolignan obovatol (1).
View Article and Find Full Text PDFWith the aim to investigate new strategies for upcycling of plastic waste, we performed aminolysis of poly(lactic acid) (PLA), using -dimethylethylenediamine (DMEDA), ,-dimethylpropylenediamine (DMPDA), and 3-aminopropylimidazole (API) as nucleophiles. The -substituted lactamides obtained were alkylated by using alkyl halides differing in alkyl chain length, obtaining organic salts that in most cases behaved as ionic liquids (ILs). Both aminolysis of PLA and alkylation of amides were carried out taking into consideration the basic principles of the holistic approach to green chemistry, applied at a laboratory scale, and carefully selecting the nature of the reaction solvent, temperature range, and amount of reagents.
View Article and Find Full Text PDFArticle Synopsis
- Researchers synthesized imidazolium and ammonium-based folate salts to create targeted chemotherapeutic agents and studied their behavior using UV-vis and fluorescence techniques.
- They analyzed the gelation properties of the salts in biocompatible solvents and used various methods (like dynamic light scattering and ATR-FTIR) to investigate the structure and interactions within the gel.
- The antiproliferative effectiveness of these salts was tested on different breast cancer cell lines and normal cells, revealing that the salts maintained their biological activity when trapped in a gel, with effectiveness varying by cell type and salt structure.
It is reported that about 10% of cystic fibrosis (CF) patients worldwide have nonsense (stop) mutations in the CFTR gene, which cause the premature termination of CFTR protein synthesis, leading to a truncated and non-functional protein. To address this issue, we investigated the possibility of rescuing the nonsense mutation (UGA) by sequence-specific RNA editing in CFTR mutant CFF-16HBEge, W1282X, and G542X human bronchial cells. We used two different base editor tools that take advantage of ADAR enzymes () to edit adenosine to inosine (A-to-I) within the mRNA: the REPAIRv2 () and the minixABE ().
View Article and Find Full Text PDF