Publications by authors named "P Cales"
Background & Aims: The accuracy of non-invasive tests (NITs) should be ≥80% (EASL recommendation). We aimed to compare the accuracies of the recommended NITs for advanced fibrosis in MASLD and improve NIT accuracy.
Methods: 1051 MASLD patients were allocated to derivation (n=637) and validation (n=414) sets.
Article Synopsis
- The study evaluated the accuracy of Agile scores (Agile 3+ and Agile 4) for diagnosing advanced liver fibrosis and cirrhosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and chronic hepatitis B or C (CHB/C).
- It included 4,243 patients and found that Agile scores had diagnostic accuracy comparable to liver stiffness measurements (LSM) in MASLD and ALD, but performed less effectively in CHB/C.
- The results suggest that using Agile scores alongside existing biomarkers like FIB-4 can improve diagnosis by reducing indeterminate results and enhancing specificity for advanced liver conditions.
Background And Aims: The prognostic weight of further decompensation in cirrhosis is still unclear. We investigated the incidence of further decompensation and its effect on mortality in patients with cirrhosis.
Approach And Results: Multicenter cohort study.
Background: Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide and the determinants driving its severity remain to be elucidated. Perfluoroalkyl substances (PFAS) are synthetic chemical compounds. They are used in commonplace products and persistent in water, soil and the human body.
View Article and Find Full Text PDFIndividual and population screening of varices needing treatment by a simple, safe and accurate test.
Clin Res Hepatol Gastroenterol
May 2023
Background: Several tests have been developed to screen varices needing treatment (VNT) in different screening settings. We aimed to develop simple estimators to quantify VNT risk and spare endoscopy while missing <5% of VNT, adapted to different screenings in the main etiologies.
Methods: 2,368 patients with chronic liver disease were included.