Creating computable algorithms for symptom management in an outpatient thoracic oncology setting.

Context: Adequate symptom management is essential to ensure quality cancer care, but symptom management is not always evidence based. Adapting and automating national guidelines for use at the point of care may enhance use by clinicians.

Objectives: This article reports on a process of adapting research evidence for use in a clinical decision support system that provided individualized symptom management recommendations to clinicians at the point of care.

EGFR-targeted therapy and related skin toxicity.

Objectives: To discuss the mechanism by which epidermal growth factor receptor (EGFR)-targeted agents work, the resulting cutaneous toxicities, the pathophysiology of the unique rash associated with these agents, and the management of these skin problems.

Data Sources: Published scientific papers, review articles, book chapters, and clinical experiences.

Conclusion: These new targeted agents result in unique cutaneous toxicities.

Larynx preservation using induction chemotherapy plus radiation therapy as an alternative to laryngectomy in advanced head and neck cancer. A long-term follow-up report.

Since 1977, we have used induction chemotherapy (CT) plus radiation therapy (RT) with curative intent in 35 advanced head and neck cancer (Ca) patients who otherwise would have required total laryngectomy. Fourteen patients had advanced Ca of the larynx or supraglottic larynx (SGL); 21 patients had Ca of the hypopharynx. In six patients the Ca was Stage III; in 26 patients it was Stage IV.

Acute hypotensive reaction to etoposide with successful rechallenge: case report and review of the literature.

Hypotension, bronchospasm, and facial flushing associated with an intravenous infusion of etoposide occurred in a 38-year-old man with advanced testicular cancer. The reaction began within three minutes after the initiation of the infusion and was reversed with intravenous fluids and diphenhydramine. He was successfully retreated with four additional doses of etoposide after pretreatment with diphenhydramine and dexamethasone.