Publications by authors named "P COSSIO"
2D template matching (2DTM) can be used to detect molecules and their assemblies in cellular cryo-EM images with high positional and orientational accuracy. While 2DTM successfully detects spherical targets such as large ribosomal subunits, challenges remain in detecting smaller and more aspherical targets in various environments. In this work, a novel 2DTM metric, referred to as the 2DTM p-value, is developed to extend the 2DTM framework to more complex applications.
View Article and Find Full Text PDFExtracting consistent statistics between relevant free energy minima of a molecular system is essential for physics, chemistry, and biology. Molecular dynamics (MD) simulations can aid in this task but are computationally expensive, especially for systems that require quantum accuracy. To overcome this challenge, we developed an approach combining enhanced sampling with deep generative models and active learning of a machine learning potential (MLP).
View Article and Find Full Text PDFArticle Synopsis
- TGF-β is a crucial protein involved in development and immunity, usually expressed in a latent form associated with its prodomain and presented on immune cells via GARP.
- Recent findings indicate that TGF-β can signal without needing to fully dissociate from its latent form, challenging existing beliefs.
- New research using advanced microscopy shows that the binding of integrin αvβ8 can alter the structure of latent TGF-β, allowing it to activate signaling pathways without being released, and this mechanism may apply to other similar receptor/ligand systems.