The Role of NK Cells and Innate Lymphoid Cells in Brain Cancer.

The brain is considered an immune privileged site due to the high selectivity of the blood-brain barrier which restricts the passage of molecules and cells into the brain parenchyma. Recent studies have highlighted active immunosurveillance mechanisms in the brain. Here we review emerging evidence for the contribution of innate lymphoid cells (ILCs) including natural killer (NK) cells to the immunosurveillance of brain cancers focusing on glioblastoma, one of the most aggressive and most common malignant primary brain tumors diagnosed in adults.

Data from experiments with tailing material and Agrostis capillaris at three scales: pot, lysimeter and field plot.

The data set consists in a file with two sheets: one includes a matrix of 297 rows and 46 columns, and the second one a matrix of 12 rows and 24 columns. In the first sheet each row is a replicate of an experimental variant with growing on tailing substrate belonging to three experiments witch have the same variants, but are organized at three scales. The data from all experiments are in the same table, with a column indicating by a code the experiment to which they belong.

Implications of spatial heterogeneity of tailing material and time scale of vegetation growth processes for the design of phytostabilisation.

Phytostabilisation projects for tailing dams depend on processes occurring at spatial scales of 10 m and at decadal time scales. Most experiments supporting the design and monitoring of such projects have much smaller spatial and time scales. Usually, they are only designed for one single scale.

Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones.

The misfolding of proteins and their accumulation in extracellular tissue compartments as insoluble amyloid or amorphous protein aggregates are a hallmark feature of many debilitating protein deposition diseases such as Alzheimer's disease, prion diseases, and type II diabetes. The plasminogen activation system is best known as an extracellular fibrinolytic system but was previously reported to also be capable of degrading amyloid fibrils. Here we show that amorphous protein aggregates interact with tissue-type plasminogen activator and plasminogen, via an exposed lysine-dependent mechanism, to efficiently generate plasmin.

Environmental metal contamination and health impact assessment in two industrial regions of Romania.

We investigated two Romanian industrial regions- Copşa Mică and Zlatna, to assess the current situation of soil pollution and bioaccumulation of Pb, Cd, Cu and Zn in different vegetable species and possible risks to consumers. Both total and mobile forms of the metals were determined in soil samples, and metal content in the edible parts of root vegetable samples was also assessed. The concentrations of Pb and Zn in soil were higher in Copşa Mică than in Zlatna (566mg/kg vs 271mg/kg for Pb and 1143mg/kg vs 368mg/kg for Zn)·The metal mobility in soil from Copsa Mica decreases in the order Zn>Cu>Cd>Pb (1.