Publications by authors named "P C Zuzarte"
The naked mole-rat (NMR; ) is a eusocial subterranean rodent with a highly unusual set of physiological traits that has attracted great interest amongst the scientific community. However, the genetic basis of most of these traits has not been elucidated. To facilitate our understanding of the molecular mechanisms underlying NMR physiology and behaviour, we generated a long-read chromosomal-level genome assembly of the NMR.
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- * The research indicates that this viral mimicry is driven by increased expression of specific genes with intronic inverted-repeat Alu elements, rather than the activation of retroelements seen in other therapies.
- * Additionally, EZH2 inhibition enhances the expression of LINE-1 retrotransposons, which contributes to genomic instability and activates immune signaling pathways, but simultaneously blocking dsRNA and DNA sensing prevents the viral mimicry effect in these tumors.
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hospital outbreaks have been common and devastating during the coronavirus disease 2019 (COVID-19) pandemic. Understanding SARS-CoV-2 transmission in these environments is critical for preventing and managing outbreaks.
Design: Outbreak investigation through epidemiological mapping and whole-genome sequencing phylogeny.