Insights into pancreatic β cell energy metabolism using rodent β cell models.

Mitochondrial diabetes is primarily caused by β-cell failure, a cell type whose unique properties are important in pathogenesis. By reducing glucose, we induced energetic stress in two rodent β-cell models to assess effects on cellular function. Culturing rat insulin-secreting INS-1 cells in low glucose conditions caused a rapid reduction in whole cell respiration, associated with elevated mitochondrial reactive oxygen species production, and an altered glucose-stimulated insulin secretion profile.

Management of pouch-vaginal fistulas - experience from our institution.

Aim: Pouch-vaginal fistula (PVF) is an uncommon but serious complication of ileo-anal pouch reconstruction. This study aimed to review the recent management of PVF, in particular the role of anti-tumour necrosis factor (anti-TNF) drugs.

Method: All patients presenting for management of PVF to our surgical service between 2007 and 2016 were studied.

The role of robotics in colorectal surgery.

Robotic surgery is safe and feasible offering many potential advantages to the colorectal surgeon.