Stable isotope evidence for pre-colonial maize agriculture and animal management in the Bolivian Amazon.

Over the past decade, multidisciplinary research has seen the Amazon Basin go from a context perceived as unfavourable for food production and large-scale human societies to one of 'garden cities', domestication, and anthropogenically influenced forests and soils. Nevertheless, direct insights into human interactions with particular crops and especially animals remain scarce across this vast area. Here we present new stable carbon and nitrogen isotope data from 86 human and 68 animal remains dating between CE ~700 and 1400 from the Llanos de Mojos, Bolivia.

Impact of race on discharge location for stroke survivors: Associations with home discharge from a retrospective analysis.

Background: White stroke survivors often experience better outcome compared to their counterparts. Poststroke discharge location influences the subsequent rehabilitation that can support recovery and improve outcomes. However, few studies have looked at the association of race and discharge to home.

Ancient genomes reveal a deep history of treponemal disease in the Americas.

Human treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most famously, syphilis. Debates on both a common origin for these pathogens and the history of syphilis itself has weighed evidence for the "Columbian hypothesis", which argues for an American origin, against that for the "pre-Columbian hypothesis", which argues for presence of the disease in Eurasia in the Medieval period and possibly earlier. While molecular data has provided a genetic basis for distinction of the typed subspecies, deep evolution of the complex has remained unresolved due to limitations in the conclusions that can be drawn from the sparse paleogenomic data currently available.

Gene Expression Dysregulation in Whole Blood of Patients with Infection.

() is a global threat and has significant implications for individuals and health care systems. Little is known about host molecular mechanisms and transcriptional changes in peripheral immune cells. This is the first gene expression study in whole blood from patients with infection.