Publications by authors named "P C Pinton"
Article Synopsis
- - p66Shc is an adaptor protein crucial for regulating cellular functions including signaling pathways, mitochondrial activity, and the production of reactive oxygen species (ROS), with its location shifting to mitochondria under oxidative stress.
- - The protein is also implicated in mitochondria-associated membranes (MAM), which play a role in key cellular processes like calcium balance, apoptosis (cell death), and autophagy (cell cleaning), suggesting p66Shc's involvement in determining cell fate.
- - This study investigates the distribution of p66Shc in different parts of mouse liver tissue and HepG2 cells, demonstrating a significant presence of p66Shc in MAM under both normal and oxidative stress conditions.
Article Synopsis
- Behçet's disease (BD) is an autoinflammatory condition affecting multiple organs, with an increase in prevalence noted in Japan (3% for BD and 4% for gastrointestinal Behçet's disease, GIBD) from 2017-2021, despite a decline in incidence.
- Treatment trends indicate that while glucocorticoids remain the most common initial therapy, the use of TNF-α inhibitors has risen significantly (5.6% for BD and 8.1% for GIBD).
- Adverse events, particularly severe ones like pneumonia, were reported in 40% of patients on TNF-α inhibitors, but about 80% maintained treatment after three years, highlighting the need for
Introduction: Chronic hand eczema (CHE) is an inflammatory skin condition characterized by different pathomechanisms, clinical presentations, and prognoses. Treatment is often challenging because of limited approved drugs, and severe CHE is associated with reduced quality of life (QoL) and poor overall health measures in terms of psychological, functional, and occupational challenges. This study aims to describe the real-life management practices of Italian dermatologists who frequently treat patients with CHE, compare these practices with existing guidelines, and propose practical clinical recommendations for the management of these patients.
View Article and Find Full Text PDFMitochondria are considered one of the main sites of reactive oxygen species (ROS) production in the eukaryotic cells. For this reason, mitochondrial dysfunction associated with increased ROS production underlies various pathological conditions as well as promotes aging. Chronically increased rates of ROS production contribute to oxidative damage to macromolecules, i.
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