Torsional Vibration Analysis Using Rotational Laser Vibrometers.

Torsional vibration is a critical phenomenon in rotor dynamics. It consists of an oscillating movement of the shaft and causes failures in multiple oscillating fields of application. This type of vibration is more difficult to measure than lateral vibration.

Intelligent Defect Diagnosis of Rolling Element Bearings under Variable Operating Conditions Using Convolutional Neural Network and Order Maps.

Vibration analysis is an established method for fault detection and diagnosis of rolling element bearings. However, it is an expert oriented exercise. To relieve the experts, the use of Artificial Intelligence (AI) techniques such as deep neural networks, especially convolutional neural networks (CNN) have gained the attention of researchers because of their image classification and recognition capability.

Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation.

This chapter presents the protocols for developing of skin equivalents (SE) and reconstructed human epidermis (RHE) models for dermal toxicity evaluation as an alternative method to animal use in research. It provides a detailed protocol for the in vitro reconstruction of human skin from primary keratinocytes, melanocytes, and fibroblasts obtained from foreskin biopsies, including the procedures for reconstruction of a stratified epidermis on a polyester membrane. SE and RHE developed through these methods have been proven suitable not only for dermal toxicity studies, but also for investigating of pathological conditions in the skin, such as diabetes and invasion of melanoma.

A Tacholess Order Tracking Method Based on Inverse Short Time Fourier Transform and Singular Value Decomposition for Bearing Fault Diagnosis.

Order tracking has been widely used to diagnose failures of variable speed rotating machines. The performance of the TOT (Time-Frequency Domain Tacholess Order Tracking) methods is based on the correct separation of the target component strictly related to the shaft rotation frequency. Currently, most of the methods have focused on obtaining the instantaneous frequency with accuracy.

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.

An open question in aggressive cancers such as melanoma is how malignant cells can shift the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a melanoma-secreted driver of an inflamed, but immune evasive, microenvironment that defines poor patient prognosis and resistance to immune checkpoint blockade. Mechanistically, MDK was found to control the transcriptome of melanoma cells, allowing for coordinated activation of nuclear factor-κB and downregulation of interferon-associated pathways.