Publications by authors named "P C Orsoni"
Despite rectal cancer being unusual before 40, fertility preservation (FP) remains a major concern for these reproductive-age women. Treatment usually involves pelvic radiotherapy, neoadjuvant chemotherapy, and surgery of rectum and mesorectum resection, at high risk of impairing fertility in women with risks of premature ovarian failure and radio-induced uterus damage. To date, there is no consensus on FP strategy for rectal cancer.
View Article and Find Full Text PDFArticle Synopsis
- Mesenchymal stem cell therapy shows promise for treating perianal Crohn's fistulas that do not respond to conventional treatments, which are challenging and debilitating.
- A documented case involved a patient who received autologous adipose-derived stromal vascular fraction (ADSVF) and microfat injections, leading to remarkable healing of the fistulas within 12 weeks and sustained improvement at 48 weeks.
- The successful outcome suggests that combining ADSVF and microfat may provide a new effective treatment approach for patients suffering from these complex fistulas associated with Crohn's disease.
Aim: Sacral nerve stimulation (SNS) has a place in the treatment algorithm for faecal incontinence (FI). However, after implantation, 15-30% of patients with FI fail to respond for unknown reasons. We investigated the effect of SNS on continence and quality of life (QOL) and tried to identify specific predictive factors of the success of permanent SNS in the treatment of FI.
View Article and Find Full Text PDFObjective: Since the first paper published by Matzel et al., in 1995, on the efficacy of sacral nerve stimulation (SNS) in patients with faecal incontinence, the indications, the contraindications, the stimulation technique and follow up of implanted patients have changed. The aim of this article was to provide a consensus opinion on the management of patients with faecal incontinence treated with SNS.
View Article and Find Full Text PDF