Publications by authors named "P C O'Leary"
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their formation remain unclear. In the present study, we used 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV signatures in three independent pan-cancer cohorts, we detected transcription-dependent, replicated-strand bias, the expected footprint of transcription-replication collision (TRC), in large tandem duplications (TDs).
View Article and Find Full Text PDFA Rare Case of Solitary Cardiac Myofibroma in an Infant.
World J Pediatr Congenit Heart Surg
January 2025
Article Synopsis
- Solitary myofibromas are rare, benign tumors mostly found in the head and neck, but this report focuses on an unusual case of a solitary cardiac myofibroma in an infant.
- A two-month-old was diagnosed with a 2×1 cm mass on the mitral papillary muscle, leading to severe heart regurgitation; imaging techniques were used to assess the mass.
- Surgical removal was performed and the patient recovered well, with follow-up showing no recurrence of the tumor and minor regurgitation issues.
The social market economies of the Western world considered the provision of plasma derivatives produced from publicly owned blood services as a legitimate state commitment and, until the last decades of the 20th century, many of the relevant jurisdictions maintained state-supported fractionation plants to convert publicly collected plasma into products for the public health system. This situation started to change in the 1990s, because of several converging factors, and currently, publicly owned/subsidized, not-for-profit fractionation activity has shrunk to a handful of players. However, the collection of plasma from publicly owned blood services has continued and recent developments have increased the interest of state authorities globally to increase the volume of plasma collected to increase the level of strategic independence in the supply of crucial plasma-derived medicines from commercial market pressures, particularly the global for-profit fractionation sector with its dominance of source plasma from paid donors in the United States.
View Article and Find Full Text PDFBackground And Objectives: Pressures on the supply of plasma-derived medicinal products (PDMPs) have led to the efforts to increase the level of plasma collected by public health authorities.
Materials And Methods: Public blood collectors were assessed regarding their routes towards domestically sourced plasma and PDMPs.
Results: The collectors' operations were specified and analysed.