Publications by authors named "P C Nachev"
Introduction: The cognitive side-effects of medication are common, but often overlooked in practice, and not routinely considered in interventional trials or post-market surveillance. The cognitive footprint of a medication seeks to quantify the impact of its cognitive effects based on magnitude, duration, and interaction with other factors, evaluated across the exposed population.
Methods: Bayesian multivariable regression analysis of retrospective population-based cross-sectional cohorts.
Pituitary neuroendocrine tumors remain one of the most common intracranial tumors. While radiomic research related to pituitary tumors is progressing, public data sets for external validation remain scarce. We introduce an open dataset comprising high-resolution T1 contrast-enhanced MR scans of 136 patients with pituitary tumors, annotated for tumor segmentation and accompanied by clinical, radiological and pathological metadata.
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- The review highlights the complexity of stroke, driven by disruptions in blood supply and complicated by the neural and vascular systems' interactions.
- Advances in machine vision and deep learning are improving predictive tools for stroke, but their clinical impact is limited by real-world data challenges.
- Although AI's potential benefits for stroke care are clear, the best approaches for practical application are still being explored, with deep generative models seen as a promising avenue for innovation.
Influential theories of complex behaviour invoke the notion of cognitive control modulated by conflict between counterfactual actions. Medial frontal cortex, notably the anterior cingulate cortex, has been variously posited as critical to such conflict detection, resolution, or monitoring, largely based on correlative data from functional imaging. Examining performance on the most widely used "conflict" task-Stroop-in a large cohort of patients with focal brain injury (N = 176), we compare anatomical patterns of lesion-inferred neural substrate dependence to those derived from functional imaging, meta-analytically summarised.
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- The study examined the management of cerebrospinal fluid (CSF) drainage in patients with acute hydrocephalus, focusing on the effects of different weaning methods and timing on outcomes.
- It included 69 adult patients, predominantly with conditions like aneurysmal subarachnoid hemorrhage, and found that delaying the initiation of drain weaning led to longer hospital stays and increased risk of complications.
- The results suggest that an early rapid wean could improve patient outcomes by shortening hospital stays and reducing mechanical issues, but emphasizes the need for better quality evidence in future research.