Publications by authors named "P C Morais"
Introduction And Objectives: The association of low-density lipoprotein cholesterol (LDL-C) levels and prognosis in patients with heart failure (HF) remains uncertain. This study aimed to evaluate the prognostic significance of LDL-C in patients admitted for acutely decompensated HF and establish a safety cut-off value in this population.
Methods: This retrospective, observational study included 167 consecutive patients admitted for acute HF.
(1) Background: Continuous health promotion systems are increasingly important, enabling decentralized patient care, providing comfort, and reducing congestion in healthcare facilities. These systems allow for treatment beyond clinical settings and support preventive monitoring. Wearable systems have become essential tools for health monitoring, but they focus mainly on physiological data, overlooking motor data evaluation.
View Article and Find Full Text PDFPolymeric coronary stents, like the ABSORB™, are commonly used to treat atherosclerosis due to their bioresorbable and cell-compatible polymer structure. However, they face challenges such as high strut thickness, high elastic recoil, and lack of radiopacity. This study aims to address these limitations by modifying degradable stents produced by additive manufacturing with poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) with degradable metallic coatings, specifically zinc (Zn) and magnesium (Mg), deposited via radiofrequency (rf) magnetron sputtering.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes mellitus is becoming a major global health issue, expected to nearly double in prevalence from 194 million in 2003 to 333 million by 2025, with 90%-95% of cases being type 2.
- New research focuses on developing dual inhibitors for type 2 diabetes through synthesizing ester and triazole derivatives of p-coumaric acid, using methods like Williamson synthesis and Microwave-assisted click reaction.
- These synthesized compounds were tested and showed effective inhibition against two key enzymes, GSK-3β kinase and DPP-IV, indicating that p-coumaric acid derivatives are promising candidates for new diabetes treatments.
The urgent need for new antimicrobial compounds has led scientists to explore antimicrobial peptides (AMPs) and antimicrobial polymers as solutions for multidrug resistance. In this study, we synthesized copolymers with cationic and hydrophobic moieties by free-radical polymerization (FRP) using a chain transfer agent to control molecular weights. The potential of natural products as part of the hydrophobic moiety was evaluated, along with variations in their monomer content (13-25%) and the molecular weight (MW) of the copolymer (5000-20,000 g·mol).
View Article and Find Full Text PDF