Publications by authors named "P C Manoria"

Adverse cardiovascular (CV) events have declined in Western countries due at least in part to aggressive risk factor control, including dyslipidemia management. The American and European (Western) dyslipidemia treatment guidelines have contributed significantly to the reduction in atherosclerotic cardiovascular disease (ASCVD) incidence in the respective populations. However, their direct extrapolation to Indian patients does not seem appropriate for the reasons described below.

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Aspergillosis mostly involves the lung and sinuses in severely immunocompromised patients like those with hematological malignancies, postorgan transplants, acquired immunodeficiency syndrome (AIDS), and secondary to chemotherapeutic agents. Duodenal aspergillosis is very rare and mostly occurs as a part of disseminated disease or in classical immunosuppressive conditions. We report a middle-aged female with uncontrolled diabetes who presented to us with epigastric pain and was finally diagnosed as a case of primary duodenal aspergillosis.

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Article Synopsis
  • The Lipid Association of India updated its cardiovascular risk assessment algorithm to address the unique challenges of atherosclerotic cardiovascular disease (ASCVD) in Indians, focusing on early intervention.
  • A series of expert meetings were held to review current evidence and refine treatment guidelines, emphasizing the need for aggressive preventive measures due to the young age of onset for ASCVD in the Indian population.
  • The updated recommendations aim to enhance LDL-C-lowering therapy and improve risk management strategies for individuals at high risk of ASCVD, ultimately striving to reduce its prevalence in India and beyond.
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In 2021 an estimated 74 million individuals had diabetes in India, almost all type 2 diabetes. More than half of patients with diabetes are estimated to be undiagnosed and more 90% have dyslipidemia that is associated with accelerated development of atherosclerotic cardiovascular disease (ASCVD). Patients of Indian descent with diabetes have multiple features that distinguish them from patients with diabetes in Western populations.

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