Publications by authors named "P C Madsen"
Background: Echolocating bats face an intense arms race with insect prey that can detect bat calls and initiate evasive maneuvers. Their high closing speeds and short biosonar ranges leave bats with only a few 100 ms between detection and capture, suggesting a reactive sensory-motor operation that might preclude tracking of escaping prey. Here we test this hypothesis using greater mouse-eared bats (Myotis myotis) as a model species.
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- mRNA vaccines, initially developed for cancer control, have emerged as crucial tools in fighting infectious diseases, particularly during the COVID-19 pandemic.
- The review explores advancements in mRNA vaccine technology, including personalized vaccines showing promise against tough cancers like pancreatic cancer and melanoma, and considers their potential against difficult tumors like glioblastoma.
- A comprehensive roadmap is presented for using mRNA vaccines to enhance cancer immunotherapy, with a focus on glioblastoma treatments through innovative combinations of RNA science and immunotherapies.
Article Synopsis
- Current prognostic tools for colorectal cancer (CRC) are inadequate, making it essential to find better methods for personalized treatment.* -
- This study investigated the role of circulating tumor DNA (ctDNA) biomarkers in predicting patient outcomes, analyzing samples from CRC patients diagnosed within 24 months.* -
- Results showed that certain methylated ctDNA markers, particularly RARB, SDC2, and WNT5A, independently predicted overall survival, recurrence-free survival, and poor prognosis, suggesting their potential use in personalized treatment strategies.*
Background: Coronary computed tomography angiography (CCTA) is recommended as the first-line diagnostic imaging modality in low-to-intermediate-risk individuals suspected of stable coronary artery disease (CAD). However, CCTA exposes patients to ionizing radiation and potentially nephrotoxic contrast agents. Invasive coronary angiography is the gold-standard investigation to guide coronary revascularisation strategy; however, invasive procedures incur an inherent risk to the patient.
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