Hyperuricemia Is Associated With Higher Mortality in Non-diabetic Heart Failure Patients.

Introduction: Hyperuricemia (HU) is associated with an increased risk of incident heart failure (HF) and adverse HF outcomes. Patients with diabetes mellitus (DM) have a greater prevalence of HU.

Aims: We evaluated the prognostic impact of HU in patients with HF according to the coexistence of DM.

Platelet distribution width-a prognosis marker in patients with chronic heart failure.

Background: Increased levels of platelet distribution width (PDW) can predict cardiac death and infarction recurrence in acute myocardial infarction. PDW appears to be a prognosis marker in acute heart failure (HF); however, its impact on chronic HF is still unknown. We investigated the impact of PDW on chronic HF.

Dynamic Response of Masonry Structures to Temperature Variations: Experimental Investigation of a Brick Masonry Wall.

Structural health monitoring (SHM) is essential for preserving historical and modern infrastructure by tracking dynamic properties such as frequencies and mode shapes. Changes in these properties can indicate structural damage, but environmental factors like temperature can also cause similar variations, complicating damage detection. This study investigates from an experimental point of view the effect of temperature on the dynamic behaviour of masonry structures, focusing on a masonry wall subjected to thermal load variations within operational conditions.

Synthesis of 1,10-Phenanthroline-2,9-bistriazoles: Evaluation as G-Quadruplex Binders and Anti-Tumor Activity.

Novel 1,10-phenanthroline-2,9-bistriazoles derivatives have been synthesized by copper-catalyzed azide/alkyne cycloaddition reactions and assessed for their ability to bind and stabilize G-quadruplex (G4) structures. Ten novel compounds were evaluated using Förster resonance energy transfer (FRET) melting, circular dichroism (CD), and fluorescence spectroscopy on several G4 sequences. Biophysical characterization led to the identification of compounds 4 a, 4 b, and 5 b as good G4 ligands of KRAS G4 sequences.

Surgical treatment of post-traumatic vertebral osteonecrosis including intravertebral expansive implants-clinical, functional and imaging outcomes and a center experience over 7 years.

Background: The effective treatment of post-traumatic vertebral osteonecrosis continues to be an under discussion and controversial subject. Armed kyphoplasty with expansive intravertebral implants is an emerging procedure, which, in theory, allow for a more effective preservation of the restored vertebral height. The development of the indications for these recent devices has given rise to auspicious outcomes in vertebral non-union situations.