Publications by authors named "P C Krause"
A role for metabolically active adipose tissue in pulmonary hypertension (PH) pathogenesis is emerging. Alterations in cellular metabolism in metabolic syndrome are triggers of PH-related vascular dysfunction. Metabolic reprogramming in proliferative pulmonary vascular cells causes a metabolic switch from oxidative phosphorylation to glycolysis.
View Article and Find Full Text PDFBackground: Segmented electrodes for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) enable directional current steering leading to expanded programming options.
Objective: This retrospective study covering a longitudinal period of up to 7 years compares the efficacy of segmented and non-segmented leads in motor symptom alleviation and reduction of dopaminergic medication in PD patients treated in a specialized center and assesses the long-term use of directional steering in clinical routine.
Methods: Demographic data and clinical scores before surgery and at 12-month follow-up (12MFU) as well as stimulation parameters at 12MFU and last follow-up (LFU) were assessed in all patients implanted with segmented leads between 01/2016 and 12/2019 and non-segmented leads in a corresponding time-period.
Article Synopsis
- Dystonia is a movement disorder linked to an imbalance in brain pathways involving the striatum and internal pallidum, but its neuronal causes are not fully understood.
- This study conducted invasive recordings from ten dystonia patients using deep brain stimulation electrodes to observe brain activity across different basal ganglia nuclei.
- Findings showed that low-frequency brain activity between the striatum and internal pallidum correlates with the severity of dystonic symptoms, highlighting the importance of the direct striato-pallidal pathway in the disorder's development.
Searches for new physics below twice the electron mass with GERDA.
Eur Phys J C Part Fields
September 2024
Article Synopsis
- A search for dark matter candidates in the mass range of 65 to 1021 keV was conducted using data from the GERDA experiment, focusing on energy depositions without detecting any significant signals above background noise.
- The study established stringent exclusion limits on dark photon and axion-like particle interactions with electrons, with specific constraints noted at a 150 keV mass level.
- Additional investigations into the decay rates of nucleons and electrons yielded lower lifetime limits for neutron, proton, and electron decay events at a 90% confidence interval.