Publications by authors named "P C Kibsey"
Unlabelled: Urinary tract infections (UTIs) pose a significant challenge to human health. Accurate and timely detection remains pivotal for effective intervention. Current urine culture techniques, while essential, often encounter challenges where urinalysis yields positive results, but subsequent culture testing produces a negative result.
View Article and Find Full Text PDFBackground: Recent studies have demonstrated the effectiveness of nirmatrelvir-ritonavir in reducing the risk of progression to severe disease among outpatients with mild to moderate coronavirus disease 2019 (COVID-19); however, data are limited regarding the use and role of nirmatrelvir-ritonavir among hospitalized patients. This study describes the use and outcomes of nirmatrelvir-ritonavir among adults hospitalized with COVID-19 in a sentinel network of Canadian acute care hospitals during the Omicron variant phase of the pandemic.
Methods: The Canadian Nosocomial Infection Surveillance Program conducts surveillance of hospitalized patients with COVID-19 in acute care hospitals across Canada.
Background: Invasive group A streptococcal disease (iGAS) is caused by group A bacteria. In 2022, multiple disease alerts for iGAS in the Island Health region, in the context of increased infections in the paediatric population in Europe and the United States, prompted further investigation into local trends. This surveillance study summarizes epidemiological trends of iGAS in the region covered by Island Health, a regional health authority in British Columbia, in 2022.
View Article and Find Full Text PDFPlasmid genomic epidemiology of carbapenemase-producing in Canada, 2010-2021.
Antimicrob Agents Chemother
December 2023
Article Synopsis
- Carbapenems are vital last-resort antibiotics against multidrug-resistant infections, but their effectiveness is threatened by the global rise of carbapenem-resistant bacteria due to carbapenemase genes.
- In Canada, a specific carbapenemase type has been identified as prevalent, capable of breaking down various antibiotics, and commonly found on mobile genetic elements like plasmids and transposons.
- Through whole genome sequencing of 829 carbapenemase-producing isolates from 2010 to 2021, researchers discovered diverse plasmid clusters responsible for resistance spread, revealing both clonal and horizontal transmission patterns across different bacterial strains in Canada.
Article Synopsis
- Trends in severe COVID-19 outcomes in Canada highlight a shift in hospitalization rates and associated risks during different waves of the pandemic, particularly higher admissions in the later waves.
- A study conducted across 155 hospitals included both adults and children, examining data from March 2020 to May 2022, focusing on severe outcomes such as ICU admissions and death rates.
- Findings indicate that while overall hospitalizations increased in later waves, the rates of severe outcomes were lower, especially among vaccinated patients compared to the unvaccinated.