Publications by authors named "P C Holland"
Groups of orthologous genes are commonly found together on the same chromosome over vast evolutionary distances. This extensive physical gene linkage, known as macrosynteny, is seen between bilaterian phyla as divergent as Chordata, Echinodermata, Mollusca, and Nemertea. Here, we report a unique pattern of genome evolution in Bryozoa, an understudied phylum of colonial invertebrates.
View Article and Find Full Text PDFBackground: In the United States, the Affordable Care Act (ACA) expanded public and private health coverage, increased health insurance affordability, reduced healthcare costs, and improved healthcare quality for many. Despite ACA provisions, lack of insurance and other factors continue to affect working-age women's access to primary care services.
Methods: We conducted a mixed-method systematic review to identify factors that affect women's access to primary care services since the ACA.
Article Synopsis
- The paradox of the great speciators describes a conflicting pattern in avian lineages in Oceania that shows broad geographic distributions indicative of strong dispersal, yet also displays significant genetic divergence suggesting limited inter-island movement.
- A study using genomic sequencing of dwarf kingfishers from northern Melanesia found deep genetic divergence and an absence of gene flow between nearby island populations, highlighting the paradox effectively.
- The research proposes a framework based on founder effects and changing selection pressures that explains how diverse traits and environmental factors influence dispersal capabilities, shedding light on the evolutionary dynamics of these bird lineages.
Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets ( = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs.
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- * Researchers synthesized a Tau segment with various PTMs and observed that these modifications generally hinder Tau's assembly into PHFs, with acetylation showing variable effects, and phosphorylation consistently reducing aggregation.
- * The findings emphasize that PTMs located outside the rigid core of Tau filaments are crucial for initiating PHF formation, illustrating the complex role of these modifications in influencing Tau aggregation dynamics.