Advances in Organoid Research and Developmental Engineering.

Over the last decade, organoid research has emerged as a transformative field in biomedical science, offering unparalleled opportunities in disease modeling, pharmacological testing, and tissue engineering [...

Ultrahigh Resolving Power Ion Mobility Spectrometry with a Simple Pulser Circuitry.

The pulsing circuitry for high resolving power drift-tube ion-mobility spectrometry is based on three avalanche photodiodes. These are switched on by illumination through optical fibers, which provide electrical insulation of the driver circuitry from the high voltage. The setup was tested with a series of quaternary ammonium ions introduced with an electrospray ion source.

Contactless Conductivity Detection for Capillary Electrophoresis-Developments From 2020 to 2024.

The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab-on-chip devices as well as fundamental and technical developments of the detector and complete electrophoresis instrumentation.

Tracking Charge Carrier Paths in Freestanding GaN/AlN Nanowires on Si(111).

Functional and abundant substrate materials are relevant for applying all sophisticated semiconductor-based device components such as nanowire arrays. In the case of GaN nanowires grown by metalorganic vapor phase epitaxy, Si(111) substrates are widely used, together with an AlN interlayer to suppress the well-known Ga-based melt-back-etching. However, the AlN interlayer can degrade the interfacial conductivity of the Si(111) substrate.

TULIPs decorate the three-dimensional genome of PFA ependymoma.

Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes from diverse childhood tumor types and uncovered a global topology in PFA that is highly reminiscent of stem and progenitor cells in a variety of human tissues.