Publications by authors named "P C Hastings"

Background: Early and delayed puberty are both associated with adverse health and psychosocial outcomes.

Objectives: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6-18 mo, on pubertal status.

Methods: This study was a follow-up to a partially double-blind randomized controlled trial.

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Article Synopsis
  • The study investigates how early-life lipid-based nutrient supplements (SQ-LNS) and home environment affect autonomic nervous system (ANS) regulation in children aged 9-11 years.
  • Participants included children from women in a Ghanaian trial where women received different nutritional supplements during pregnancy and postpartum.
  • Results show that those who received SQ-LNS or multiple micronutrients exhibited greater heart rate reactivity, while a better home environment was linked to more favorable ANS responses, indicating that early nutrition and the home setting play crucial roles in ANS development.
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Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in cancer cells. The mechanisms and enzymes regulating these events are largely unknown. Here, we investigated templated insertions in yeast at DSBs using amplicon sequencing across a repaired locus.

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Article Synopsis
  • Warm and supportive parenting is linked to better emotion regulation in children, but less is understood about its impact on adolescents, especially during a time when mental health issues often emerge.
  • The study focused on how maternal and paternal warmth from ages 10 to 16 affects adolescents' respiratory sinus arrhythmia (RSA), a measure related to emotion regulation, at age 17 in a sample of 229 Mexican-origin youths.
  • Results indicated that increases in maternal warmth during adolescence were connected to higher RSA in youths, suggesting that positive maternal interactions can enhance emotional regulation capabilities in teens.
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