Publications by authors named "P C H Cheong"
The [1,2]-rearrangement of allylic ammonium ylides is traditionally observed as a competitive minor pathway alongside the thermally allowed [2,3]-sigmatropic rearrangement. Concerted [1,2]-rearrangements are formally forbidden, with these processes believed to proceed through homolytic C-N bond fission of the ylide, followed by radical-radical recombination. The challenges associated with developing a catalytic enantioselective [1,2]-rearrangement of allylic ammonium ylides therefore lie in biasing the reaction pathway to favor the [1,2]-reaction product, alongside controlling a stereoselective radical-radical recombination event.
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- - Newborn screening (NBS) has significantly advanced public health, particularly with innovations like tandem mass spectrometry, and is expected to further evolve with genomic testing.
- - While NBS typically involves multiple low-cost confirmation tests, there's concern about the feasibility of repeating expensive genetic tests like whole-genome sequencing for follow-up.
- - The study explores how to transition NBS data into diagnostic-grade data using single-nucleotide variants (SNVs), aiming to enhance rapid diagnosis and reduce family stress when genetic issues are suspected in newborns.
Purpose: This study aims to investigate the feasibility of the home-based parent- mediated intervention Naturalistic developmental behavioral intervention (HB-NDBI) in underserved Taiwanese families of children with Autism spectrum disorder (ASD) and explore its effects on children's developmental skills and parents' parenting stress.
Method: 24 underserved Taiwanese families of children with ASD (mean age = 46.5 months) received 12-week HB-NDBI programs.