Publications by authors named "P C Grossi"
Objectives: We aim to investigate cognitive phenotype distribution and MRI correlates across pediatric-, elderly-, and adult-onset MS patients as a function of disease duration.
Methods: In this cross-sectional study, we enrolled 1262 MS patients and 238 healthy controls, with neurological and cognitive assessments. A subset of 222 MS patients and 92 controls underwent 3T-MRI scan for brain atrophy and lesion analysis.
Introduction: Infections significantly impact morbidity and mortality in lung transplant (LuTx) recipients. This survey focused on documenting current practices regarding the prevention and management of infections in LuTx in Italy.
Methods: A 52-question survey was administered online in the period from December 1, 2023, to January 31, 2024, assessing center characteristics, Tx team organization, microbiological investigations, infection prevention, and management.
A Delphi consensus-seeking procedure was conducted to validate a list of ICD-9-CM codes that could help identify hospital admissions in which antimicrobials are more likely to be prescribed. The panel agreed to include 2967 codes out of 16229 (18.28%).
View Article and Find Full Text PDFSARS-CoV-2 infection represents a new challenge for solid organ transplantation (SOT) with evolving recommendations. A cross-sectional survey was performed (February-June 2024) to describe practices among Member States of the Council of Europe (COE) on the use of organs from deceased donors with resolved or active SARS-CoV-2 infection. Overall, 32 out of 47 Member States with a transplant program participated in the study.
View Article and Find Full Text PDFArticle Synopsis
- Kaposi sarcoma herpesvirus/human herpesvirus-8 (HHV-8) poses serious health risks for solid organ transplant recipients, with higher seroprevalence noted in recipients (8.4%) compared to donors (3.3%).
- Among transplant patients, a specific group of donors (D+) and recipients (R-) showed notable rates of HHV-8-related diseases, like Kaposi sarcoma (KS) and associated inflammatory cytokine syndrome (KICS), emphasizing the importance of careful monitoring.
- Effective management of HHV-8 diseases, such as KICS, suggests that treatment options like rituximab can significantly impact patient outcomes, highlighting the need for serologic screening and timely interventions.