Publications by authors named "P C Goldsmith"
Introduction: The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies. O-GlcNAcylation, an important post-translational modification of tau and many other proteins, is significantly decreased in brain tissue of AD patients relative to healthy controls. Increased tau O-GlcNAcylation has been shown to reduce tau pathology in mouse in vivo tauopathy models.
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- Diaphragmatic hernias, traditionally linked to birth defects or trauma, can also occur due to surgical procedures, as shown in a rare case involving a 59-year-old woman after pericardial window surgery.
- The patient experienced shortness of breath post-surgery, and imaging revealed an intrapericardial diaphragmatic hernia, leading to an open surgery for repair.
- This case underscores the importance of recognizing and addressing rare complications like these postoperatively, highlighting the need for careful planning and intervention to prevent serious cardiac issues.
Article Synopsis
- - The study investigates the effects of a 2019 kidney offering scheme in the UK on older patients (aged 60+) who received kidney transplants, comparing outcomes before and after the scheme's implementation.
- - Researchers analyzed data from two groups: older adults who had transplants under the old (2006) scheme and those under the new (2019) scheme, focusing on factors like re-intervention and critical care admission.
- - Results indicated that those in the 2019 scheme faced higher odds of needing additional interventions and critical care, as well as less favorable HLA matches and an increase in repeat transplants for patients requiring more complex matching.
Volenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial.
Nephrol Dial Transplant
December 2024
Background: Volenrelaxin is a half-life-extended recombinant human relaxin protein developed for improving kidney perfusion and cardiorenal function. This study assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of volenrelaxin following single- and multiple-ascending doses (SAD and MAD) administration.
Methods: In this Phase 1, four-part, randomized, double-blinded, placebo-controlled SAD and MAD study in healthy participants, SAD participants (n = 56) received an intravenous or subcutaneous dose of volenrelaxin or placebo in a dose-ascending manner.
Peritoneal inclusion cysts (PICs) are a rare and benign condition of uncertain pathogenesis. The fluid-filled, mesothelial-lined cysts manifest within the abdominopelvic cavity. This case report details an unusual occurrence of a 97 mm PIC- presenting as an umbilical hernia- in a 26-year-old male patient with no prior surgical history.
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