Publications by authors named "P C Estes"
Article Synopsis
- The Bio-Hermes Study aimed to create a database of blood-based and digital biomarkers to enhance the detection of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- The study involved 887 participants who were evaluated using Cognivue Clarity and amyloid PET scans, successfully differentiating between cognitively normal individuals, those with MCI, and probable AD with significant accuracy.
- Results indicated that Cognivue Clarity is effective in detecting cognitive impairments and could improve patient identification for treatment protocols and clinical trial recruitment.
Article Synopsis
- - The study focuses on the challenges of detecting cognitive impairment in diverse older adults, highlighting the limitations of current assessment tools and the potential recruitment issues for Alzheimer's disease research among minoritized groups.
- - It tests the effectiveness of the Cognivue Clarity® screening platform by comparing its performance against the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) among a diverse sample of 452 participants, focusing on various demographic factors.
- - Findings show that Cognivue Clarity demonstrated strong reliability and validity, with a solid four-factor structure identified, making it a promising tool for identifying cognitive impairment and facilitating the recruitment of eligible candidates for Alzheimer's research.
Article Synopsis
- - The study aimed to identify cut-off scores for classifying cognitive impairment and to evaluate the safety and efficacy of a cognitive assessment tool, Cognivue, within a large validation study.
- - Two cohort studies were conducted with adults aged 55-95 at risk for cognitive decline, examining the alignment of Cognivue scores with a reference test called the St. Louis University Mental Status (SLUMS) through various statistical analyses.
- - Results indicated that specific Cognivue score ranges corresponded to cognitive impairment levels, with good agreement between Cognivue and SLUMS scores, and indicated reliability across multiple testing sessions.
Infectious vaginitis due to bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and accounts for a significant proportion of all gynecologic visits in the United States. A prospective multicenter clinical study was conducted to validate the performance of two new diagnostic transcription-mediated amplification nucleic acid amplification tests (NAATs) for diagnosis of BV, VVC, and trichomoniasis. Patient- and clinician-collected vaginal-swab samples obtained from women with symptoms of vaginitis were tested with the Aptima BV and Aptima vaginitis (CV/TV) assays.
View Article and Find Full Text PDF() encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric division, and proliferation control. Lgl's human orthologs, HUGL1 and HUGL2, are altered in human cancers, however, its mechanistic role as a tumor suppressor remains poorly understood. Based on a previously established connection between Lgl and Fragile X protein (FMRP), a miRNA-associated translational regulator, we hypothesized that Lgl may exert its role as a tumor suppressor by interacting with the miRNA pathway.
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