Design and Characterization of Fast-Dissolving Oral Film of Apixaban.

Background: Following the COVID-19 pandemic, microvascular and macrovascular thrombotic problems emerged that required anticoagulants. Apixaban (RN) is a factor Xa inhibitor that treats deep vein thrombosis and the two forms of artery diseases (coronary artery disease and peripheral artery disease).

Materials And Methods: The study objective was to create fast-disintegrating Apixaban Oral Thin Films (OTF) with the help of various super disintegrants to shorten disintegration time and enhance drug release in order to assist patients who have difficulty in swallowing conventional dosage forms and increase bioavailability.

Computer Assisted Objective Assessment of Micro-Neurosurgical Skills From Intraoperative Videos.

Conventionally, a surgeon's skill is assessed through visual observation by experts and by tracking patient outcomes. These techniques are very subjective and demands enormous time and effort. Hence, the aim of this study is to construct a framework for automated objective assessment of micro-neurosurgical skill.

Strategies for enhancing the efficacy of anaerobic digestion of food industry wastewater: An insight into bioreactor types, challenges, and future scope.

Food waste have become a growing concern worldwide with raising population and economic growth. Wastewater discharged from food industries contains many valuable and toxic components that have a negative impact on the ecological system. Large amounts of wastewater are discharged from the food industry, which necessitates the creation of effective technologies.

Automated Microsurgical Tool Segmentation and Characterization in Intra-Operative Neurosurgical Videos.

Checklist based routine evaluation of surgical skills in any medical school demands quality time and effort from the supervising expert and is highly influenced by assessor bias. Alternatively, automated video based surgical skill assessment is a simple and viable method to analyse surgical dexterity offline without the need for acute presence of an expert surgeon throughout the surgery. In this paper, a novel approach and results for the automated segmentation of microsurgical instruments from the real-world neurosurgical video dataset was presented.

2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations.

In this current work we have prepared a Schiff base ligand, () derived from 5- nitropyridine-2-amine with 4-hydroxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, H-NMR, C-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of assays viz.