Publications by authors named "P C Cury"
Article Synopsis
- The systematic review analyzed multiple studies to determine the effectiveness of the micronucleus assay for monitoring genetic damage in workers exposed to anesthetic gases.
- A total of 18 articles were included after thorough screening, with quality assessments rating 12 as strong, 3 as moderate, and 3 as weak.
- Overall, the findings suggest that exposure to anesthetic agents can lead to genetic damage, and the micronucleus assay is a reliable biomarker for detecting this damage in affected professionals.
The present study aims to provide a systematic review of studies on the essential and nonessential metal exposure at occupational level, genotoxicity, and polymorphisms and to answer the following questions: Are genetic polymorphisms involved in metal-induced genotoxicity? In this study, 14 publications were carefully analyzed in this setting. Our results pointed out an association between polymorphism and genotoxicity in individuals exposed to metals, because 13 studies (out of 14) revealed positive relations between genotoxicity and polymorphisms in xenobiotics metabolizing and DNA repair genes. Regarding the quality of these findings, they can be considered reliable, as the vast majority of the studies (12 out of 14) were categorized as strong or moderate in the quality assessment.
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- * A case study is presented involving a 61-year-old woman with a metastatic nodule on her tongue that appeared normal on the surface, highlighting the need for careful examination in similar cases.
- * The final diagnosis of colorectal metastasis was confirmed through clinical, histopathological, and immunohistochemical analysis, emphasizing the importance of these methods in identifying rare metastatic lesions.
Introduction: Septic shock, a life-threatening condition, can result in cerebral dysfunction and heightened mortality rates. In these patients, disturbances in cerebral hemodynamics, as reflected by impairment of myogenic cerebral autoregulation (CA), metabolic regulation, expressed by critical closing pressure (CrCP) and reductions in intracranial compliance (ICC), can adversely impact septic shock outcomes. The general recommendation is to maintain a target mean arterial pressure (MAP) of 65 mmHg but the effect of different MAP targets on cerebral hemodynamics in these patients is not clear and optimal targets might be dependent on the status of CA.
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