Conquering Overtreatment of DCIS: Lessons from PRECISION.

As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al.

Magnetic vortex: Fundamental physics, developments, and device applications.

A magnetic vortex (MV) is one of the fundamental and topologically nontrivial spin textures in condensed matter physics. Magnetic vortices are usually the ground states in geometrically restricted ferromagnets with zero magnetocrystalline anisotropy. Magnetic vortices have recently been proposed for use in a variety of spintronics applications due to their resistance to thermal perturbations, flexibility in changing core polarity, simple patterning procedure, and potential uses in magnetic data storage with substantial density, sensors for the magnetic field, devices for logic operations, and other related fields.

Assembly and performance of a cholera RDT prototype that detects both and associated bacteriophage as a proxy for pathogen detection.

Cholera rapid diagnostic tests (RDTs) are vulnerable to virulent bacteriophage predation. We hypothesized that an enhanced cholera RDT that detects the common virulent bacteriophage ICP1 might serve as a proxy for pathogen detection. We previously developed a monoclonal antibody (mAb) to the ICP1 major capsid protein.

Garra zubzaensis, a new fish species (Cyprinidae: Labeoninae) from the Brahmaputra River basin, Nagaland, North-Eastern India.

A new species of Garra (Labeoninae) is described from the Zubza River, a headwater of the Brahmaputra River basin, in Kohima district of Nagaland, North-eastern India. The new species is distinguished by the following combination of characters: a black spot located on the principal ray and first three branched rays of the dorsal (upper) lobe distal part, as well as a black submarginal V-shaped band on the principal ray and whole branched rays of the ventral (lower) lobe of caudal fin; snout with weakly-developed proboscis represented by slightly upwards elevated hump, with no transverse groove and no transverse lobe, and with 10-12 small tubercles on anterodorsal marginal aspect; 34 lateral-line scales including two pored scales on caudal fin; absence of scales on chest and presence of poorly developed scales on belly; relatively shorter caudal peduncle (10.7-12.