Publications by authors named "P C Batel"
Background And Aims: Pre-clinical studies suggest that the simultaneous blockade of the α1b and 5HT2A receptors may be effective in reducing alcohol consumption. This study aimed to assess the efficacy and safety of prazosin (α1b blocker) and cyproheptadine (5HT2A blocker) combination in decreasing total alcohol consumption (TAC) in alcohol use disorder (AUD).
Design, Setting And Participants: This was a double-blind, parallel group, placebo-controlled, Phase 2, randomized clinical trial conducted in 32 addiction treatment centres in France.
Aims: The estimated effect of sodium oxybate (SMO) in the treatment of alcohol dependence is heterogeneous. Population severity and treatment duration have been identified as potential effect modifiers. Population severity distinguishes heavy drinking patients with <14 days of abstinence before treatment initiation (high-severity population) from other patients (mild-severity population).
View Article and Find Full Text PDFUnlabelled: Cocaine-induced transient hallucinations (CIH) are a frequent complication following cocaine intake that is associated with addiction severity.
Methods: Two hundred and forty-two non-psychotic and Caucasian lifetime cocaine users were included in a French multicentric study. Clinical variables and dopamine pathway genotype data were extracted and tested with CIH scores using a zero-inflated binomial model, which allows for the exploration of factors associated with occurrence and severity separately.
Article Synopsis
- - Sodium oxybate (SMO) has been approved in some European countries for helping individuals with alcohol dependence maintain abstinence, although there are concerns about potential misuse outside of its intended use.
- - A phase IIb clinical trial tested a new formulation of SMO on 509 alcohol-dependent patients with varying severity of dependence, observing an unexpectedly high response to placebo.
- - While the main goal of increasing days abstinent wasn't achieved for all patients, there were significant positive results for those with severe dependence, suggesting that future studies should focus on baseline severity when evaluating SMO's effectiveness.