Publications by authors named "P Brugarolas"
Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models.
View Article and Find Full Text PDFSpinal cord injuries (SCIs) often lead to lifelong disability. Among the various types of injuries, incomplete and discomplete injuries, where some axons remain intact, offer potential for recovery. However, demyelination of these spared axons can worsen disability.
View Article and Find Full Text PDFPositron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information associated with pain of different etiologies. As such, the information obtained using PET often combined with MRI or CT can provide useful information for diagnosing and monitoring changes associated with pain.
View Article and Find Full Text PDFArticle Synopsis
- The compound [F]3-fluoro-4-aminopyridine ([F]3F4AP) is the first PET radioligand targeting K channels in the brain to image demyelination, but it shows lower metabolic stability in awake humans compared to anesthetized animals, affecting its brain uptake.!* -
- A new compound, 5-methyl-3-fluoro-4-aminopyridine (5Me3F4AP), has been developed, exhibiting similar binding affinity and properties to [F]3F4AP, but with a slower metabolic rate, making it a potential alternative for K channel imaging.!* -
- The synthesis of [F]5Me
Article Synopsis
- The development of theranostic agents using alpha emitters addresses a significant clinical need, focusing on combining therapeutic and diagnostic functions in medicine.* -
- A new ligand, macropa-F, was created to effectively bind to alpha therapeutic radiometals, and its properties were tested with lead-203 and bismuth-207 as substitutes for actual alpha-emitting isotopes.* -
- The resulting fluorine-18 and radiometal complexes demonstrated high stability in human serum for several days, showcasing a promising approach for theranostic applications in medicine.*