Publications by authors named "P Brogan"
Mevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive review provides an updated perspective on MKD, including its aetiology, pathogenesis, diagnostic modalities, and therapeutic strategies. Based on recent research and clinical advances, our objective is to bridge the knowledge gaps in the 2015 SHARE guidelines.
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- IgA nephropathy and IgA vasculitis with nephritis are kidney conditions that can occur in kids, but they're pretty rare.
- Unlike adults, children often show more severe symptoms quickly, like blood in their urine, and their kidneys look more inflamed when doctors check.
- There's not a lot of good information on how to treat these conditions because they're different in kids, and experts from around the world are trying to figure out better ways to help affected children.
Objectives: To elicit and quantify expert opinion concerning the relative merits of two treatments for a rare inflammatory disease: Juvenile dermatomyositis (JDM). The formal expression of expert opinion reported in this paper will be used in a Bayesian analysis of a forthcoming randomised controlled trial known as BARJDM (baricitinib for juvenile dermatomyositis).
Methods: A Bayesian prior elicitation meeting was convened, following a previously described methodological template.