Publications by authors named "P Breuer"
Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5.
Acta Neuropathol Commun
December 2024
Severity and outcome of strokes following cerebral hypoperfusion are significantly influenced by stress responses of the blood vessels. In this context, brain endothelial cells (BEC) regulate inflammation, angiogenesis and the vascular resistance to rapidly restore perfusion. Despite the relevance of these responses for infarct volume and tissue recovery, their transcriptional control in BEC is not well characterized.
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- - The study focuses on synucleinopathies, specifically Parkinson's disease (PD), characterized by the buildup of α-synuclein protein in the brain and other tissues.
- - Researchers examined blood samples from familial PD patients with G51D mutations and sporadic PD patients, finding that levels of stable α-synuclein tetramers were lower compared to control groups.
- - The decrease in α-synuclein tetramers was also observed in asymptomatic G51D carriers, suggesting that destabilization of these proteins may occur before the onset of PD symptoms, pointing to their potential use as early biomarkers for the disease.
The spinocerebellar ataxias (SCA) comprise a group of inherited neurodegenerative diseases. Machado-Joseph Disease (MJD) or spinocerebellar ataxia 3 (SCA3) is the most common autosomal dominant form, caused by the expansion of CAG repeats within the ataxin-3 (ATXN3) gene. This mutation results in the expression of an abnormal protein containing long polyglutamine (polyQ) stretches that confers a toxic gain of function and leads to misfolding and aggregation of ATXN3 in neurons.
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- - The spinocerebellar ataxias (SCA), especially SCA3, are inherited neurodegenerative diseases caused by mutations in the ATXN3 gene, leading to toxic protein aggregation in neurons.
- - Researchers conducted a high-throughput screening of 2,640 compounds to find modulators of ATXN3 and discovered that statins, particularly Simvastatin, enhanced the expression of ATXN3.
- - Simvastatin increased ATXN3 mRNA and protein levels in both normal and patient-derived cells, suggesting its potential as a treatment option for SCA3 by affecting the gene's expression.
Glioblastoma is the most common and aggressive primary tumor of the central nervous system with poor outcome. Current gold standard treatment is surgical resection followed by a combination of radio- and chemotherapy. Efficacy of temozolomide (TMZ), the primary chemotherapeutic agent, depends on the DNA methylation status of the O6-methylguanine DNA methyltransferase (MGMT), which has been identified as a prognostic biomarker in glioblastoma patients.
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