Publications by authors named "P Botarelli"
[Peculiar features of childhood poisoning and in the maternal-fetal period].
Ann Ist Super Sanita
February 2007
Article Synopsis
- Acute toxic exposures in children are common in Paediatric Emergency Medicine, but research, particularly in Italy, is limited.
- This paper is the first to explore both the epidemiological and clinical aspects of acute poisoning in children across Italy.
- Findings indicate a rise in the use of activated charcoal for treatment and the effectiveness of short stay observation units, although further research with more centers is needed to address ongoing controversies.
T-lymphocyte response to hepatitis C virus in different clinical courses of infection.
Gastroenterology
February 1993
Background: To assess the role played by the immune response in the outcome of hepatitis C virus infection, the CD4+ T-lymphocyte response to viral antigens was studied in infected individuals with different clinical courses.
Methods: Using six recombinant proteins of hepatitis C virus, the study assessed the proliferative responses of peripheral blood mononuclear cells from 41 patients with chronic hepatitis C, 11 patients whose chronic hepatitis was successfully treated with interferon alfa and 11 healthy HCV seropositive individuals.
Results: (1) Sixty-five percent of hepatitis C virus-seropositive individuals had CD4+ T-cell responses to viral proteins.
Hepatitis B virus (HBV) is one of the most important causes of chronic liver disease. HBV is a DNA virus with an external glycoprotein surface and an internal nucleocapsid which contains the viral genome. HBV infection is revealed by the appearance of specific markers.
View Article and Find Full Text PDFB-cell dysfunction in HIV-infected children is reflected by hypergammaglobulinemia and high levels of serum IgA. Little is known about antibody specificity since only a small portion of serum IgA appears to be directed against HIV proteins. In the present study the specificity of IgA antibodies against food, inhalant, bacterial and fungi antigens were evaluated in a population of HIV infected children.
View Article and Find Full Text PDFThe HIV envelope protein gp120 is heavily glycosylated, having 55% of its molecular mass contributed by N-linked carbohydrates. We investigated the role of N-glycosylation in presentation of HIV-gp120 to T cells. T cell clones obtained from humans immunized with a recombinant nonglycosylated form of HIV-gp120 (env 2-3) were studied for their ability to recognize both env 2-3 and glycosylated gp120.
View Article and Find Full Text PDF