Publications by authors named "P Bortoletto"
Research Question: Could a predictive model, using data from all US fertility clinics reporting to the Society for Assisted Reproductive Technology, estimate the likelihood of patients using their stored oocytes?
Design: Multiple learner algorithms, including penalized regressions, random forests, gradient boosting machine, linear discriminant analysis and bootstrap aggregating decision trees were used. Data were split into training and test datasets. Patient demographics, medical and fertility diagnoses, partner information and geographic locations were analysed.
Article Synopsis
- A CRESS-DNA virus, primarily found in fecal samples from vertebrates, was examined in human vaginal samples for its presence.
- Viral metagenomics was conducted on samples from 28 healthy women in NYC, with some providing duplicates over a 12-21 day span.
- The study found that one individual had continuous detection of the CRESS-DNA virus over a twelve-day period, indicating it can persist in the human vagina.
Study Question: What is the impact of male age- and sperm-related factors on embryonic aneuploidy?
Summary Answer: Using a 3-fold analysis framework encompassing patient-level, embryo-level, and matching analysis, we found no clinically significant interactions between male age and sperm quality with embryo ploidy.
What Is Known Already: While the effect of maternal age on embryo chromosomal aneuploidy is well-established, the impact of male age and sperm quality on ploidy is less well-defined.
Study Design, Size, Duration: This retrospective cohort study analyzed autologous preimplantation genetic testing for aneuploidy (PGT-A) and frozen embryo transfer cycles from December 2014 to June 2021.
Article Synopsis
- * Out of 29 women studied, 18 tested positive for HPV, showing a significant increase from initial visits to after hormone stimulation.
- * Analysis identified various HPV types, notably under two genera, with some sequences potentially representing new types.