Publications by authors named "P Borst"

Background: Increasing numbers of patients receiving oral anticoagulants are undergoing elective surgery. Low molecular weight heparin (LMWH) is frequently applied as bridging therapy during perioperative interruption of anticoagulation. The aim of this study was to explore the postoperative bleeding risk of patients receiving surgery under bridging anticoagulation.

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This paper presents a personal, selective, and sometimes critical retrospective of the history of ABC transporters in multidrug resistance (MDR) of cancer cells, overrepresenting discoveries of some early pioneers, long forgotten, and highlights of research in Amsterdam, mainly focussing on discoveries made with disruptions of ABC genes in mice (KO mice) and on the role of ABC transporters in causing drug resistance in a mouse model of mammary cancer. The history is complemented by a list of erroneous concepts often found in papers and grant applications submitted anno 2020.

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Article Synopsis
  • The article reviews the history and development of the malate-aspartate shuttle (MAS) from its inception in 1962 to recent discoveries in 2020, highlighting its role in oxidizing cytosolic NADH in mammalian tissues like liver and heart.
  • Key findings revealed that the efflux of aspartate from mitochondria, crucial for MAS function, depends on the proton-motive force, demonstrating that the MAS primarily facilitates the oxidation of cytosolic NADH and affects the NADH/NAD ratio.
  • Current research continues to explore the MAS's implications in tumors and mitochondrial defects, with recent discoveries uncovering new genetic deficiencies related to MAS, emphasizing its ongoing relevance in biological research.
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