Publications by authors named "P Borrione"
Metformin (Met) is a drug commonly prescribed in type 2 diabetes mellitus. Its efficacy is due to the suppression of hepatic gluconeogenesis, enhancement of peripheral glucose uptake and lower glucose absorption by the intestine. Recent studies have reported Met efficacy in other clinical applications, such as age-related diseases.
View Article and Find Full Text PDFBackground: The effects of Anabolic Androgenic Steroids (AAS) are largely illustrated through Androgen Receptor induced gene transcription, yet RNA-Seq has yet to be conducted on human whole blood and skeletal muscle. Investigating the transcriptional signature of AAS in blood may aid AAS detection and in muscle further understanding of AAS induced hypertrophy.
Methods: Males aged 20-42 were recruited and sampled once: sedentary controls (C), resistance trained lifters (RT) and resistance trained current AAS users (RT-AS) who ceased exposure ≤ 2 or ≥ 10 weeks prior to sampling.
This study aims to investigate how metformin (Met) affects muscle tissue by evaluating the drug effects on proliferating, differentiating, and differentiated C2C12 cells. Moreover, we also investigated the role of 5'-adenosine monophosphate-activated protein kinase (AMPK) in the mechanism of action of Met. C2C12 myoblasts were cultured in growth medium with or without Met (250μM, 1mM and 10mM) for different times.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of a mixture of trehalose, spermidine, nicotinamide, and polyphenols on muscle injury in endurance athletes, focusing on oxidative stress and autophagy.
- Results showed that after 30 days of supplementation, athletes experienced a significant reduction in oxidative stress and muscle injury biomarkers.
- The findings suggest that this mixture can improve muscle recovery and could also benefit individuals with muscle injuries, like cancer or cardiovascular patients, and the elderly.
Objective: It remains unknown whether myonuclei remain elevated post anabolic-androgenic steroid (AAS) usage in humans. Limited data exist on AAS-induced changes in gene expression.
Design: Cross-sectional/longitudinal.