Impact of Peru's women's emergency centres on the reporting of physical, psychological and sexual intimate partner violence.

Background: Violence against women is a global problem with serious consequences. In response, Peru established women's emergency centres or Centros de Emergencia Mujer (CEMs) in 1999, offering support services like psychological and legal counselling for women suffering from violence. CEMs also implemented preventive activities such as educational programmes and community outreach to prevent domestic violence.

Mechanical and rheological properties of Pluronic F127 based-hydrogels loaded with chitosan grafted with hyaluronic acid and propolis, focused to atopic dermatitis treatment.

Hydrogels for biomedical applications have been widely studied once they are able to enhance the wound-healing process, as well as facilitate the controlled release and loading of drugs. In this context, Pluronic F127 (PF127) has a major role as it was shown to have exceptional versatility, once it holds unique gelation properties, as it is thermoreversible and is liquid in lower temperatures, and changes to gel in higher temperatures. Moreover, the gelation behavior of PF127 is influenced by its concentration and can be further modulated by incorporating different compounds, including drugs.

Vaccine Development: Lessons, Challenges, and Future Innovations.

is an opportunistic pathogen with a multidrug-resistant profile that has become a critical threat to global public health. It is one of the main causes of severe nosocomial infections, including ventilator-associated pneumonia, chronic infections in patients with cystic fibrosis, and bloodstream infections in immunosuppressed individuals. Development of vaccines against is a major challenge owing to the high capacity of this bacterium to form biofilms, its wide arsenal of virulence factors (including secretion systems, lipopolysaccharides, and outer membrane proteins), and its ability to evade the host immune system.

Evidence from Tinshemet Cave in Israel suggests behavioural uniformity across Homo groups in the Levantine mid-Middle Palaeolithic circa 130,000-80,000 years ago.

The south Levantine mid-Middle Palaeolithic (mid-MP; ~130-80 thousand years ago (ka)) is remarkable for its exceptional evidence of human morphological variability, with contemporaneous fossils of Homo sapiens and Neanderthal-like hominins. Yet, it remains unclear whether these hominins adhered to discrete behavioural sets or whether regional-scale intergroup interactions could have homogenized mid-MP behaviour. Here we report on our discoveries at Tinshemet Cave, Israel.

Genome-scale resources in the infant gut symbiont Bifidobacterium breve reveal genetic determinants of colonization and host-microbe interactions.

Bifidobacteria represent a dominant constituent of human gut microbiomes during infancy, influencing nutrition, immune development, and resistance to infection. Despite interest in bifidobacteria as a live biotic therapy, our understanding of colonization, host-microbe interactions, and the health-promoting effects of bifidobacteria is limited. To address these major knowledge gaps, we used a large-scale genetic approach to create a mutant fitness compendium in Bifidobacterium breve.