Publications by authors named "P Bonnard"
Article Synopsis
- The study aimed to create a simple scoring system to identify patients needing hepatitis B treatment in resource-limited countries, particularly in Africa, where conventional assessment tools are often inaccessible and expensive.
- Researchers validated this score using data from patients in The Gambia and other African nations, focusing on two main factors: HBV e antigen (HBeAg) and alanine aminotransferase (ALT) levels.
- The resulting score, TREAT-B, showed strong diagnostic accuracy for treatment eligibility, with a sensitivity of 85% and specificity of 77%, making it a practical tool for clinicians in African settings.
In Egypt, as elsewhere, liver biopsy (LB) remains the gold standard to assess liver fibrosis in chronic hepatitis C (CHC) and is required to decide whether a treatment should be proposed. Many of its disadvantages have led to develop noninvasive methods to replace LB. These new methods should be evaluated in Egypt, where circulating virus genotype 4 (G4), increased body mass index and co-infection with schistosomiasis may interfere with liver fibrosis assessment.
View Article and Find Full Text PDFBackground & Aims: HCV requires host lipid metabolism for replication, and apolipoproteins have been implicated in the response to treatment.
Methods: We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patients with symptomatic acute hepatitis C (aHCV); those undergoing treatment for chronic hepatitis C (cHCV); and HIV/HCV co-infected patients being treated for their chronic hepatitis C. We also evaluated associations between apolipoproteins and IL28B polymorphisms, a defined genetic determinant of viral clearance.