Publications by authors named "P Boireau"
Article Synopsis
- Modern agriculture has significantly improved global food security and human health, but it also faces challenges like ecosystem degradation and increasing disease risks.
- The commentary discusses these challenges through the One Health perspective, highlighting issues such as zoonotic diseases and antimicrobial resistance linked to intensive agricultural practices.
- It emphasizes the need for adopting good agricultural practices supported by technology and education to achieve sustainable development across all sectors within the agrifood system.
Article Synopsis
- - The infection leads to cyst formation in host muscle cells, allowing the pathogen to avoid the immune response and grow, but the specific factors and mechanisms behind this are not well understood.
- - Researchers discovered that a protein called -RNF, secreted by the pathogen, is essential for its growth and development inside host cells.
- - The -RNF protein acts as an E3 ubiquitin ligase, modifying the SQSTM1/p62 protein in a way that disrupts the normal process of autophagy, which is critical for clearing damaged mitochondria and supports abnormal muscle cell development.
Article Synopsis
- * A study assessed the presence of the parasite's DNA in various pig tissues post-infection and during the processing of dry sausages, revealing that DNA was found in a majority of muscle samples and hearts, with varying parasite concentrations.
- * Most processed pork products tested positive for the parasite, indicating a concerning level of contamination; however, the distribution of the parasites was uneven across different tissues, and some samples showed concentrations below detectable limits.
The parasitic nematode Trichinella has a special relationship with its host as it has a unique intracellular location within the feeder cell which is a structure derived from skeletal muscle fiber. It has been proposed that "parakines" secreted by Trichinella larvae serve as messengers to implement communication between the parasite and the muscle cells through a molecular cross-talk to ensure permanent coexistence within the host. The Ts-NBL1 protein is considered to be a potential key "parakine" involved in the early invasion of the muscle fiber and its transformation into a feeder cell during Trichinella spiralis infection.
View Article and Find Full Text PDFThis article introduces the Parasite issue dedicated to part of the research in social sciences supported by the Domaine d'Intérêt Majeur de la Région Île-de-France (DIM) One Health [2016-2022]. We show how the four papers of this special issue are related. Jérôme Michalon recalls the genealogy of One Health and analyzes it as an "epistemic watchword".
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