Publications by authors named "P Blandin"

Article Synopsis
  • The development of vascular networks in microfluidic chips is essential for cultivating 3D cell aggregates like spheroids and organoids, as it supports their long-term survival.
  • Despite advancements in microfluidics and organoid technology, creating vascularized organoids-on-chips is still a challenge due to their complexity and the inadequacies of current devices.
  • The introduced platform successfully forms endothelial networks around various spheroids and organoids, enhancing their growth and function while allowing for monitoring and intravascular perfusion, marking progress in organ-on-chip models for tissue engineering.
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In this article, we are presenting an original selective plane illumination fluorescence microscope dedicated to image "Organ-on-chip"-like biostructures in microfluidic chips. In order to be able to morphologically analyze volumetric samples in development at the cellular scale inside microfluidic chambers, the setup presents a compromise between relatively large field of view (∼ 200 µm) and moderate resolution (∼ 5 µm). The microscope is based on a simple design, built around the chip and its microfluidic environment to allow 3D imaging inside the chip.

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PhotoPlethysmoGraphy (PPG) is ubiquitously employed in wearable devices for health monitoring. Photodiode signal inversion is observed in rare occasions, most of the time when the sensor is pressed against the skin. We report in this article such observations made at the right common carotid artery site.

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The detection of body fluids (e.g., blood, saliva or semen) provides information that is important both for the investigation and for the choice of the analytical protocols.

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Assessing the relative importance of geographical and ecological drivers of evolution is paramount to understand the diversification of species and traits at the macroevolutionary scale. Here, we use an integrative approach, combining phylogenetics, biogeography, ecology and quantified phenotypes to investigate the drivers of both species and phenotypic diversification of the iconic Neotropical butterfly genus Morpho. We generated a time-calibrated phylogeny for all known species and inferred historical biogeography.

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