Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality.

Purpose: Evaluation of efficacy and safety of proton radiation therapy (PRT) for medium- and large-size choroidal melanoma with focus on preservation of the eye and its function.

Methods: Retrospective review of 78 patients with 60 medium and 18 large-size choroidal melanomas at a median follow-up of 34 months.

Results: The 5-year data for local control, metastases-free survival, and disease-specific survival were estimated to be 90.

Proton beam irradiation of subfoveal choroidal neovascularisation in age-related macular degeneration.

Purpose: To assess the safety and potential toxicity of proton beam radiation in the treatment of subfoveal choroidal neovascular membrane (CNVM) due to age-related manner degeneration (ARMD) in a prospective, non-randomised study.

Methods: Forty-eight eyes of 46 consecutive patients with subfoveal CNVM due to ARMD, not amenable to laser photocoagulation, were treated prospectively with a single proton beam exposure. Two dose regimens were evaluated: 8 CGE (Cobalt Gray Equivalent) and 14 CGE.

Phase I/II study of proton beam irradiation for the treatment of subfoveal choroidal neovascularization in age-related macular degeneration: treatment techniques and preliminary results.

Purpose: Age-related macular degeneration is the prevalent etiology of subfoveal choroidal neovascularization (CNV). The only effective treatment is laser photocoagulation, which is associated with decreased visual acuity following treatment in most patients. This study assessed both the response of subfoveal CNV to proton beam irradiation and treatment-related morbidity.

Pigmented tumor and acute visual loss.

A 22-year-old man presents with a history of blurring of vision in his right eye. Ophthalmologic examination reveals a pigmented mass obscuring his optic disc. Two weeks later the patient experienced the apoplectic onset of visual loss to light perception.