The abundance change of age-regulated secreted proteins affects lifespan of C. elegans.

Proteome integrity is vital for survival and failure to maintain it results in uncontrolled protein abundances, misfolding and aggregation which cause proteotoxicity. In multicellular organisms, proteotoxic stress is communicated among tissues to maintain proteome integrity for organismal stress resistance and survival. However, the nature of these signalling molecules and their regulation in extracellular space is largely unknown.

Shift of the reduction potential of nickel(II) Schiff base complexes in the presence of redox innocent metal ions.

With the objective of gaining insight into the modulation of the reduction potential of the Ni(II/I) couple, we have synthesized two mononuclear nickel(II) complexes, NiL (HL = ,'-bis(3-methoxysalicylidene)-1,2-diamino-2-methylpropane) and NiL (HL = ,'-bis(3-methoxysalicylidene)-1,3-diamino-2,2-dimethylpropane) of two NO donor ligands and recorded their cyclic voltammograms. Both the nickel complexes show reversible reduction processes for the Ni(II/I) couple in acetonitrile solution but the reduction potential of NiL ( = -1.883 V) is 188 mV more positive than that of NiL ( = -2.

Granulomatous amoebic encephalitis due to spp complicating multidrug-resistant tuberculous meningitis in an immunocompetent individual.

Granulomatous amoebic encephalitis due to spp is a rare, near-fatal central nervous system infection. It is often seen in immunocompromised individuals. Here we describe a survivor of this infection who was co-infected with multidrug-resistant tuberculosis.

UV-assisted photochemical transformation of a tetranuclear copper(II) complex: a DFT supported study on β-lactamase inhibitory activity towards antibiotic resistance.

Herein, we present a dark-green crystalline tetranuclear Cu(II) Schiff base complex {C1 = [CuL](ClO)(DMF)(HO)} using a N,N,O donor ligand (HL), namely 2-(((2-hydroxypropyl)imino)methyl)-6-methoxyphenol. Spectro-photometrical investigation on the β-lactamase-like activity of this coordinately saturated system revealed its catalytic inefficiency towards hydrolysis of nitrocefin as a model substrate. This complex has attracted significant interest as a promising photo-catalyst owing to its narrow band gap (2.

Cu(II)-Ln(III) (Ln = Gd, Tb and Dy) complexes of an unsymmetrical NO donor ligand: field induced SMM behaviour of Cu(II)-Tb(III) complexes.

Three new hetero-metallic Cu-Ln complexes [(CuL)Gd(NO)(CHOH)] (1), [(CuL)Tb(NO)(HO)]·[CuL] (2) and [(CuL)Dy(NO)(HO)]·[CuL] (3) have been synthesized using a mono-nuclear Cu(II) complex, [CuL], of an unsymmetrically di-condensed NO donor Schiff base ligand, -(3-methoxysalicylidene)--(salicylidene)-1,2-ethylenediamine (HL). Single crystal X-ray crystallography revealed that complex 1 is a nitrate bridged 1D chain of dinuclear Cu(II)-Gd(III) units whereas in 2 and 3, the dinuclear Cu(II)-Ln(III) units are co-crystallized with a [CuL] unit. The Ln(III) centers are nine coordinated with the geometry of a spherical capped square antiprism for Gd and spherical tricapped trigonal prism for Tb and Dy.